Addio agli studi: L impatto dei fattori sociali e delle motivazioni individuali sulla scelta di abbandonare l universita

Il nucleo centrale del lavoro consiste proprio nel tentativo di identificare i differenti ordini di motivazioni che si trovano all origine della scelta di lasciare gli studi, di quantificarne l incidenza e di analizzarne le caratteristiche.Il nucleo centrale del lavoro consiste proprio nel tentativo di identificare i differenti ordini di motivazioni che si trovano all origine della scelta di lasciare gli studi, di quantificarne l incidenza e di analizzarne le caratteristiche

Mitral Valve Transcatheter Edge-to-Edge Repair:1-Year Outcomes From the MiCLASP Study

Background: Mitral transcatheter edge-to-edge repair (M-TEER) is a guideline-recommended treatment option for patients with severe symptomatic mitral regurgitation (MR). Outcomes with the PASCAL system in a post-market setting have not been established. Objectives: The authors report 30-day and 1-year outcomes from the MiCLASP (Transcatheter Repair of Mitral Regurgitation with Edwards PASCAL Transcatheter Valve Repair System) European post-market clinical follow-up study. Methods: Patients with symptomatic, clinically significant MR were prospectively enrolled. The primary safety endpoint was clinical events committee–adjudicated 30-day composite major adverse event rate and the primary effectiveness endpoint was echocardiographic core laboratory–assessed MR severity at discharge compared with baseline. Clinical, echocardiographic, functional, and quality-of-life outcomes were assessed at 1 year. Results: A total of 544 patients were enrolled (59% functional MR, 30% degenerative MR). The 30-day composite major adverse event rate was 6.8%. MR reduction was significant from baseline to discharge and sustained at 1 year with 98% of patients achieving MR ≤2+ and 82.6% MR ≤1+ (all P &lt; 0.001 vs baseline). One-year Kaplan-Meier estimate for survival was 87.3%, and freedom from heart failure hospitalization was 84.3%. Significant functional and quality-of-life improvements were observed at 1 year, including 71.6% in NYHA functional class I/II, 14.4-point increase in Kansas City Cardiomyopathy Questionnaire score, and 24.2-m improvement in 6-minute walk distance (all P &lt; 0.001 vs baseline). Conclusions: One-year outcomes of this large cohort from the MiCLASP study demonstrate continued safety and effectiveness of M-TEER with the PASCAL system in a post-market setting. Results demonstrate high survival and freedom from heart failure hospitalization, significant and sustained MR reduction, and improvements in symptoms, functional capacity, and quality of life.</p

A Common Atom Model for the Bayesian Nonparametric Analysis of Nested Data

The use of high-dimensional data for targeted therapeutic interventions requires new ways to characterize the heterogeneity observed across subgroups of a specific population. In particular, models for partially exchangeable data are needed for inference on nested datasets, where the observations are assumed to be organized in different units and some sharing of information is required to learn distinctive features of the units. In this manuscript, we propose a nested Common Atoms Model (CAM) that is particularly suited for the analysis of nested datasets where the distributions of the units are expected to differ only over a small fraction of the observations sampled from each unit. The proposed CAM allows a two-layered clustering at the distributional and observational level and is amenable to scalable posterior inference through the use of a computationally efficient nested slice-sampler algorithm. We further discuss how to extend the proposed modeling framework to handle discrete measurements, and we conduct posterior inference on a real microbiome dataset from a diet swap study to investigate how the alterations in intestinal microbiota composition are associated with different eating habits. We further investigate the performance of our model in capturing true distributional structures in the population by means of a simulation study

Validazione della actuator control unit del laboratorio fly-by-wire del dia con attuatore ht p/n p533a0001-00 s/n saas005

Lo scopo del presente documento è fornire prove che confermino l’equivalenza tra l’elettronica di controllo e comando dell’attuatore HT P/N P533A0001-00 S/N SAAS005 del velivolo AAEM M346 impiegata presso il DIA (di seguito definita Actuator Control Unit, ACU) e quella effettivamente utilizzata nei Flight Control Computer del velivolo (di seguito definita Actuator Interface Module, AIM)

Tropospheric ozone in alpine forest sites: air quality monitoring and statistical data analysis

Biological injuries to forest ecosystems in two lateral valleys of Valtellina (Italy) have been studied. The selected areas are characterized by different forest novel decline symptoms and ozone concentration levels. Analyses of meteorological and air quality data collected by fixed and mobile stations located in the two valleys are presented. Ozone concentration has been measured both by passive samplers and continuos analyzers and the ozone vertical gradient in one valley has been determined. In order to investigate the relation between emission sources, ambient ozone levels and plant biological injuries, a modeling research project has been started. As preliminary results the wind field obtained by the application of two diagnostic meteorological models, MINERVE and CALMET, and the computation of the biogenic emissions are presented. Some examples of spatial distribution and temporal trend of the most important pollutants emitted by plants are discussed

Convalidazione modello attuatore HT P/N P533A0001-00 S/N SAAS00

Il presente lavoro documenta le attività condotte presso il Dipartimento di Ingegneria Aerospaziale dell'Università di Pisa sulla realizzazione di un modello, implementato in ambiente Matlab/Simulink, in grado di riprodurre, a differenti temperature di esercizio, la dinamica dell’attuatore HT P/N P533A0001-00 S/N SAAS005 del velivolo Alenia Aermacchi M346. Lo sviluppo e la messa a punto del modello sono state effettuate sulla base di prove condotte sulla servovalvola DDV (Direct Drive Valve) dell’attuatore e sull’attuatore completo. In particolare, i test sulla servovalvola sono stati effettuati sia a temperatura ambiente che in condizioni di controllo di temperatura ambientale in camera climatica, mentre i test sull’attuatore completo sono stati effettuati a temperatura ambiente. L’estesa campagna sperimentale ha previsto lo svolgimento di test sia statici (isteresi e motor gain di servovalvola) che dinamici (risposte in frequenza di ciclo aperto e di ciclo chiuso con varie ampiezze di comando) a diverse ampiezze di comando in modo da evidenziare e caratterizzare le nonlinearità del sistema . A completamento dello studio si è infine fornita una predizione, mediante simulazione, del comportamento in temperatura dell’attuatore completo, ponendo l’accento su alcune possibili problematiche di controllo

Risultati dei test sull’attuatore ht p/n p533a0001-00 s/n saas005 nel range di temperatura da -54 °C a +71 °C

Il presente lavoro documenta le attività condotte presso il Dipartimento di Ingegneria Aerospaziale dell'Università di Pisa sulla caratterizzazione sperimentale, a differenti temperature di esercizio, della dinamica della servovalvola Direct Drive (DDV) integrata nell’attuatore HT P/N P533A0001-00 S/N SAAS005 del velivolo Alenia Aermacchi M346. La campagna di prove si è concretizzata in test di isteresi a piccoli e grandi comandi e in test di risposta in frequenza di ciclo aperto e di ciclo chiuso con varie ampiezze di comando. Per tale attività è stata utilizzata una camera climatica, appositamente acquisita dal DIA, per l’effettuazione sulla DDV di un’estesa campagna di prove statiche e dinamiche a temperatura ambiente e alle temperature di -54°C, -40°C, -20°C e 71°C